The sodium hyaluronate is a stable polysaccharide or polymer that belongs to the group of glycosaminoglycans. These are primarily found in connective tissue, bone, and epithelial tissue. This means that it is present in many parts of the human body, such as synovial fluid, vitreous humor, or eye fluid, internal tissues, and skin cells, among others. There are countless organic parts that contain and can be receptors of using sodium hyaluronate.
Perhaps you have heard or read an article where sodium hyaluronate or hyaluronic acid is mentioned interchangeably, but I will tell you that they are different at the molecular level. The difference lies in the fact that sodium hyaluronate is hyaluronic acid bonded to sodium salt, meaning sodium salt of hyaluronic acid. As for the differences in our body, they are practically the same, which is why they are often referred to by either name. In the end, almost everyone refers to the same thing, and depending on the context in which it is named, you can usually tell which one is being referred to: sodium hyaluronate or hyaluronic acid.
One of the particularities and properties of this substance is that the body absorbs it normally after 25 to 30 days from the moment it is administered. Regardless of the route of administration, it is assimilated without side effects.
Next, we will describe the uses of sodium hyaluronate.
Properties of sodium hyaluronate
It has different properties depending on where it is found, but the main ones are to protect and maintain moisture.
Sodium hyaluronate in joints is in a viscous state that provides resistance and mobility of the limbs. Due to its density, which is higher than that of water, it allows smooth movement of the cartilage without friction. It is part of an impact cushioning system. Sodium hyaluronate for joints is presented as a gel with medicinal properties and is used to replenish synovial fluid through infiltrations.
In the eyes it facilitates movement, prevents irritation, and maintains the visual organ in optimal moisturizing conditions. When there is a low presence of this substance, dry eye syndrome appears with irritation and ocular dryness. The format used for the eyes is drops or eye drops.
In the skin, the substance found is hyaluronic acid, which, along with collagen, is one of the most important components for enabling cell regeneration and maintenance. Together, these two substances promote water retention and the creation and renewal of essential cells and fibers. Here we find a wide variety of formats, such as creams, gels, shampoos, etc. There is such a variety that it is impossible to list all the forms currently available. There is also the possibility of obtaining hyaluronic acid in dietary supplements. This is usually in powder or capsule form.
Types of products with sodium hyaluronate
- Drops
- Gel
- Injections
If we focus on the saline formulation and not on hyaluronic acid, there are three types of solutions available, ranging from ophthalmic sodium hyaluronate or eye drops to intraarticular injections.
Brands
- Fragon
- Hyabak
- Acuaiss
- Oddent
- Visionlux
- Hyalgan
- Suprahyal
- Monovisc
Just as with the formats and formulations, almost all pharmaceutical companies offer some type of sodium hyaluronate in their product catalog, as you can see in the list of brands.
I want to know the benefits and consequences of using this in aesthetics.
Ana, on the blog, you’ll find a lot of information about the properties of sodium hyaluronate, its benefits, and side effects when used in different ways. Take a look at the “Infiltrations and Injections” category, where we talk about injectable hyaluronic acid in several articles. If you can’t find it, just let me know, and I’ll give you a hand.
I don’t have money to buy Perlane hyaluronic acid and want to use the one for osteoarthritis, which is cheaper. Can I inject it into my face? This is the easy question no one answers.
Mauro, each product has specific indications and works differently. The sodium hyaluronate used for osteoarthritis, which is for the joints, is more viscous and works as a lubricant to prevent friction between the cartilage and bones. The effects of hyaluronic acid or hyaluronate for the face are for filling. The molecular structure is different, even though they share the same name.
I would like to know where sodium hyaluronate comes from, is it of natural or synthetic origin?
Thank you very much, and congratulations on the website.
Puede realizarse la extracción de distintas fuentes, aunque para el hialuronato sódico que se utiliza para inyectar en estética lo normal es que sea sintético.
Good afternoon,
How can I get this product in Colombia since I was prescribed Hyalgan and I can’t find it? Under what other name can I get it?
Thank you.
You can ask the person who prescribed it to you, as they will surely know where you can buy it where you live, or they can suggest a similar product since they will know the amount you need. There is Synvisc, but although it is hyaluronic acid, it is not exactly the same, so I recommend confirming it before buying the ampoules. The number of sessions may be different for it to work and show results. It has a different molecular weight.
Euflexxa is another sodium hyaluronate-based product for injection into joints, but the same applies. It’s best to ask first so you don’t spend money on something that might not work, as you won’t be able to benefit from it if it doesn’t. If it’s prescribed, it’s because it will be available somewhere, and they can surely guide you.
Another option I suggest is that you speak with a pharmacist to see if they can order it for you.
Espero te sirva.
Sodium hyaluronate infiltration: can it alter blood sugar levels in diabetics?
It has no interactions with glucose or blood sugar.
Good morning! I asked at an aesthetic clinic about facial hyaluronic acid injections, and the product they showed me is Cystistat. It sounded like cystitis, and it said sodium hyaluronic acid. Is this a recommended product for that use? Thank you very much.
Cystistat hyaluronic acid is from Rubió Laboratories and is designed to replenish the lack of glycosaminoglycans in the urinary bladder.
I was looking for a product in a lab to make some creams, but they didn’t have it, and they offered me sodium hyaluronate. It was new to me, it comes in powder, and I was curious if I can use it for topical use.
From what I’ve researched, it’s 1 gram per 99 ml of water. Does it work this way?
Hello Eduardo, the best thing is to ask where you bought it so they can tell you its purity and method of application.
Hello, I have a question. My mom started using eye drops with sodium hyaluronate 0.4% prescribed by the ophthalmologist for dryness, but I noticed that her eyelashes were falling out. Is this normal, or is it an allergic reaction to this medication?
Hello, it is not normal, and if it were due to an allergic reaction to a preservative in the eye drops, it should show typical signs of contact allergy, such as dermatitis on the eyelids or allergic or toxic conjunctivitis.
Hello, I have a problem after injecting sodium hyaluronate between my eyebrows. I feel a lot of itching and a headache, and I’ve been told that there is a way to dissolve it with an injection. Is this possible? Because this is a torment. Thank you.
If it is a controlled product, it is completely hypoallergenic.
Hello, what is the price of facial filler ampoules, and how many are needed for the treatment? Thank you.
For supplements in pill form, which is better, hyaluronate or hyaluronic acid? I mean for everything: joints, skin, etc. (Initially, I would mix it with collagen, as I was told they go well together).
Best regards.
I just had an infiltration of Artromex Plus (sodium hyaluronate 20 mg) in my knee due to knee osteoarthritis. Two days have passed, and now I have more acute pain than before the infiltration, and I can’t move my leg. Perhaps the injection was placed in the wrong location. I had this done at the Hospital de la Solidaridad in Magdalena. I would like to know if anyone else has had this infiltration and how it went. Please leave me a message.
Hello, I would like to know more information about the medication Cystistat. I also read that it contains sodium hyaluronate. We want to use this medication for an instillation in the bladder of a female patient, but our question is, what benefits does it have in relation to chronic cystitis (which has bleeding in the bladder)? What is the price of this medication in Mexico? I hope you can help me, please.
I have knee osteoarthritis. What is the difference between Artromex Plus and Suprahyal? I have only been infiltrated with three syringes of Artromex Plus.
Alex, how has it been going with Artromex Plus? Has it improved your condition? Have they only infiltrated you three times? I have been prescribed 5 ampoules at Essalud in Trujillo, Peru, but I haven’t bought them yet because they are not available at the insurance, and they cost S/ 227 each.
Friend Gladys Ávila, I’m sorry they didn’t respond to your comment. However, I ask you, how is your knee and leg doing? Have you improved? Have you continued with more injections or suspended the treatment? Thank you very much for your response.
Hello, I have been prescribed Artromex-plus, three injections in the knee, but I see a case here where it causes a lot of pain. How is this? Should I get it or not? It is supposed to be for pain relief…!!!!
Hello Ketty, the infiltration with sodium hyaluronate in the knee is to relieve pain, although some people seem not to experience the desired effects, meaning they have side effects, although this is a low percentage. In any case, if your orthopedic specialist advises you to use it, follow their instructions.
I want to buy injections for the knee.
Thinking I was taking Ultralevura, I mistakenly ingested a teaspoon of sodium hyaluronate from my wife’s eye drops with yogurt. I would like to know if it could have a negative effect.
Hello Eduardo, in principle, you should not have any side effects from taking sodium hyaluronate. The eyes are very sensitive, and for it to affect the stomach or other parts, the eye drops would need to contain strong substances, which is not good for the eyes. Don’t worry about the confusion.
Good evening, I have received an injection of 25 mg of Artromex in each knee from the 10 doses prescribed by my doctor. My question is, how much rest do I need after each session? I was ordered to stay in bed for 48 hours; couldn’t it be done differently?
I would like to know where I can buy high molecular weight hyaluronic acid powder for cosmetology in Mexico. Thank you very much. Alicia Espejel
Good evening, I would like to know the dose at which I could administer this substance in the preparation of a moisturizing shampoo.
Hello, good afternoon, I would like to know if there is any contraindication for the use of treatments with one application per week for 4 weeks in patients with severe hypertension due to the sodium salt content.
Your article says… “The difference lies in the fact that sodium hyaluronate is hyaluronic acid bound to sodium salt, that is, sodium salt of hyaluronic acid.”
Hello, I have a question about whether the hyaluronic acid used in dermal fillers is combined with sodium chloride or not. Also, if the sodium hyaluronate used in cataract surgery with a high concentration of around 24-30 mg/ml of hyaluronic acid and a viscosity of about 500,000 mPas is equivalent to the one used in dermal fillers. Thank you very much.
Good afternoon, where can I find hyaluronic acid for expression lines? Thank you.
Good evening, I had surgery on the bags under my eyes, and the surgeon prescribed me Peptivel ZQ. I started reading and saw that it contains sodium hyaluronate. Is that correct, and how does it help me?
It will improve the hydration of the skin in the area where you apply it, and this will help regenerate the tissue better.